Hair type-specific function of canonical Wnt activity in adult mouse skin
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چکیده
منابع مشابه
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Wnts regulate important intracellular signaling events, and dysregulation of the Wnt pathway has been linked to human disease. Here, we uncover numerous Wnt canonical effectors in human platelets where Wnts, their receptors, and downstream signaling components have not been previously described. We demonstrate that the Wnt3a ligand inhibits platelet adhesion, activation, dense granule secretion...
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Skin and leather characteristics of hair-type goats were studied in relation to their sex and age, using 100 randomly-selected skin from goats reared in east west Iran. Mean weights of skin and leather were 859.2±35.2 and 357.4±16.2 g, and the length and width of leather ranged from 60 to 121 and 41 to 87 cm, respectively. Age had a significant effect on the weight and area of skin and leather....
متن کاملCanonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?
OBJECTIVE Because aberrant Wnt signaling has been linked with systemic sclerosis (SSc) and pulmonary fibrosis, we sought to investigate the effect of Wnt-10b on skin homeostasis and differentiation in transgenic mice and in explanted mesenchymal cells. METHODS The expression of Wnt-10b in patients with SSc and in a mouse model of fibrosis was investigated. The skin phenotype and biochemical c...
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2014
ISSN: 0906-6705
DOI: 10.1111/exd.12509